Piperacillin/Tazobactam

Generic Name : Piperacillin/Tazobactam
Pronunciation : PI-per-a-SIL-in/TAZ-oh-BAK-tam
TradeName : India- Adzopip Vial, Ampip-T, Baclin Inj, Boxter Inj, Cadipip Vial, Cidal Vial, Cinpip-Tz Vial, Combiwin Vial, Cureact Inj, Durataz Vial, Elzox Vial, Europep-T Inj, Everpip-Tz Inj, Forpep Vial, Gotaz Vial, Gramotaz Vial, Hoslin Inj, Ip-Taz Vial, Jope Inj, Kombat Inj, Kpt Inj, Lazocin Forte Vial, Lazopip Vial, Lintaz Vial, Lupitaz Inj Vial, Mezobact-P Inj, Microtaz Vial, Monal Inj, Novacillin Plus Vial, Olin Vial, Pactum Vial, P-Bact Inj, Penitaz Vial, Pibact Vial, Piplak-Tbz Vial, Pipmax Inj Vial, Pipranem Inj, Piprapen-T Inj Vial, Pipras-T Vial, Piprid-Tz Inj, Piptac Vial, Piptal Vial, Piptamate Vial, Piptaz Vial, Piptochek Vial, Pipven-Tbz Vial, Pipvig-Tbz Vial, Pipzac Inj, Piraz Vial, Pirotaz Inj, Pisa Vial, Prazobact Vial, Pt-Nac Inj, Raprozo Vial, Recopep-T Inj, Revotaz Vial, Rifco Vial, Sanotaz Inj, Santaz Vial, Sinibec Inj, Sipracillin-Tz Inj, Systapip-Tz Inj, Tacidal Inj, Tavera Inj, Tazact Vial, Tazar Vial, Tazcillin Vial, Taze Vial, Tazilin Vial, Tazin Vial, Tazira Ivvial, Tazit Inj, Tazkair Vial, Tazo Pip Inj, Tazobid Inj, Tazofast Vial, Tazolead Inj, Tazolife Vial, Tazolin Inj, Tazonex Vial, Tazonis Vial, Tazo-P Vial, Tazopen Vial, Tazopep Vial, Tazopra Vial, Tazopro 4.5 Gm Inj, Tazorid-P Vial, Tazotum Vial, Tobz Vial, Torbac Vial, Widemix Inj, Zenopip Inj, Zob Inj, Zobactin Vial, Zocillin Inj, Zontum Inj, Zopercin Vial, Zoplin Inj, Zopymed 4.5 Vial, Zopymed Vial, Zosyn Vial, Zovirex Vial.
International- Zosyn.
Why it is prescribed (Indications) :
This combination medication is an antibacterial agent, prescribed for various infections such as Nosocomial pneumonia. It blocks the bacteria's cell wall growth, which kills the bacteria. Tazobactam inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
When it is not to be taken (Contraindications) :
Hypersensitivity.
When it is to be taken :
IV- The recommended dose is 3.375 mg 4 times a day, for 7 to 10 days. A higher initial dose of 4.5 mg 4 times a day may be used for more severe infections.
How it should be taken :
It comes as a solution for injection, administered by a healthcare provider.
Special Instruction :
*Caution should be exercised in patients with history of asthma; hay fever; or kidney, liver, or gastrointestinal disease (especially colitis), during pregnancy and breastfeeding.
*Repeated electrolyte estimations may be needed especially in patients with low potassium levels.
*Monitor blood functions regularly.
Side Effects :

It may lead to increase risk of fever, rashes in patients with cystic fibrosis, bleeding, super infections, convulsions, kidney failure.
Allergic Reactions- Diarrhea, severe allergic reactions, skin rashes, itching, occasionally platelet mediated bleeding, rigors, malaise, inflammation in stomach.
Local- Injection-site reactions such as pain, swelling, redness, indurations and vein inflammation.
Gastrointestinal- Inflammation of stomach, hairy tongue, inflammation of colon, nausea and vomiting, blood in stool.
Genitourinary- Urine retention, painful urination.
Blood- Decrease in white blood cells.
Lab- Increase in liver enzymes, blood urea nitrogen, and presence of red blood cells in urine.
Miscellaneous- Chills, facial swelling, mucosal bleeding, tightness in throat.
Other Precautions :
*Continue to use this medication until the full prescribed amount is finished.
Storage Conditions :
Injection vials should be stored at (20-25°C) room temperature prior to reconstitution.